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Search Result For 'Veterinary medicine' , Result Number : 34

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Tarek Soliman Mohamed Ali
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Veterinary medicine
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Abd El-Kader M. A., Madeha A. Ayoub and Ahlam A. Gharib (2005) Survival Of Enterohaemorrhagic Escherichia.coli O157:H7 Of Faecal Origin In Yoghurt Under Different Environmental Condition Proceedings the 8th Scientific Conference Biotechnology and Animal Wealth Development, Cairo University, Faculty of Veterinary Medicine17-19 April Giza,Egypt, 53 (2): 537-544.
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Ahlam A.Gharib, Mohamed M. E. M, Gabal M. E. M. and Enany M. E. (2004) CLONING AND EXPRESSION OF ampR-β-LACTMASE GENE FROM ZOONOTIC A.hydrophila IN E.coli. Suez Canal Veterinary Medicine Journal. (SCVMJ) Special Issue for the 3th Scintific Conference November ,vol.VII(1) 2004.
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Ahlam A. Gharib, Adel Attia MA and Bendary M. (2013) Detection Of The coa Gene In Staphylococcus aureus From Different Sources By Polymerase Chain Reaction. Suez Canal Veterinary Medicine Journal. (SCVMJ),XVII(1) pp.167-177.
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Asawy A. M. E., Ahlam A. Gharib and Ahmed M. A. H. (2004) EVALUATION OF POLYMERASE CHAIN REACTION (PCR) AS DIAGNOSTIC METHOD WITH OTHER CONVENTIONAL METHODS OF BRUCELLA IN RUMINANTS. Seventh ScientificVeterinary Medical Conference ,The Role Of Veterinary Medicine In The Development of Animal Wealth and Puplic Health Protection Zagazig Univerisity, Faculty of Veterinary Medicine 7th S.C.,21-23 July 2004 Sharm El-Sheik,South Sinai –A.R. Egypt.
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Mohamed A. A. Mohamed, M. E. M and Ahlam A. Gharib (2004) ZOONOTIC IMPORTANCE OF ARCOBACTER SPECIES WITH REFERENCE TO ITS PROTEIN PROFILE Seventh ScientificVeterinary Medical Conference ,The Role Of Veterinary Medicine In The Development of Animal Wealth and Puplic Health Protection Zagazig Univerisity, Faculty of Veterinary Medicine 7th S.C.,21-23 July 2004 Sharm El-Sheik,South Sinai –A.R. Egypt.
Ahlaam Abd Al Aziz Gharieb Ibrahim
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Mohamed M. E. M., Mohamed A.A. and Ahlam,A.Gharib (2003) ZOONOTIC AND MICROBIOLOGICAL ASPECTS OF ESCHERICHIA COLI O:157 WITH SPECIAL REFERENCE TO ITS RAPD –PCR Veterinary Medical Journal 51( 4), 2003 Faculty of Veterinary Medicine-Cairo University-Giza
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
AJVS. Vol. 52(1): 81-86. January, 2017 DOI: 10.5455/ajvs.248866 Using Nonlinear Models to Describe Body Weight Growth Curves in Three Different Lines of Japanese Quail Fatma D.M. Abdallah Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, 44511Egypt. Abstract Key words: Nonlinear model, growth curve, Japanese quail. The aim of this study was to choose the best predictive model for the accurate description of data of 240 quail's body weight. Non-linear function models were used for estimating growth curves in three lines of Japanese quail, high, low and control. The non-linear models which used were Gompertz, Brody and Logistic model. The models were fitted to weight-age data, from hatch (0), 2, 4 to 6 weeks of age of 240 quails. The weight-age data were modeled by using non-linear regression procedure of Statgraphics statistical package program. Model parameters were estimated using the Levenberg–Marquardt algorithm and comparisons among models were done based on mean square error, adjusted coefficient of determination, Akaike information criterion (AIC) and number of iterations. The results showed that the body development of the three lines could be illustrated well by three models. The Logistic and Gompertz growth curve model were fitted to data especially in high group where adjusted coefficient of determination is 97.7246 and 97.5972 respectively. The smallest value of Akaike information criterion (AIC) was 1138.80 high line in Logistic model. The Gompertz model is better in case of low line and the Logistic model is better in case of high and control line. The logistic model gives the best fit of data followed by the Gompertz. The Brody equation was found to be unsuitable in control group.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
AJVS. Vol. 60 (1): 49-54 Jan. 2019 DOI: 10.5455/ajvs.16828 Statistical Approaches for Treatments over Time (Repeated Observations) in Nile Tilapia Fatma D.M. Abdallah Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, 44511Egypt. ABSTRACT Key words: Repeated measure ANOVA, sphericity assumptions, lysozymes, P value and Bonferroni procedure. This study aims to model and analyze repeated observations in some biological sciences and veterinary practices (Nile tilapia fish). Repeated measure ANOVA is used to assess the effect of some treatments over a specific time. Data obtained from an experimental study examining the effect of some immunostimulants (Spirulina platensis (SP) and Salvia officinalis (SO)) on lysozymes activity in Nile tilapia fish which measured repeatedly at two times. The analysis is applied by using the software SPSS version 20 on the data collected at two time points 14th day and 28th day so the correct test was two way repeated measure design. The assumptions of the test were achieved where Huynh-Feldt and Greenhouse-Geisser measures were not significant (P-value > 0.05). The P value for time, treatments and the interaction of them was 0.000, so they have a highly significant effect on the (outcome variable) lysozymes activity of Nile tilapia. Bonferroni correction is used as a post hoc test and its result showed a difference between the groups for each parameter. These results of univariate analysis agreed with the multivariate analysis results.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Applied Mathematics 2019, 9(1): 1-5 DOI: 10.5923/j.am.20190901.01 Role of Time Series Analysis in Forecasting Egg Production Depending on ARIMA Model Fatma D. M. Abdallah Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt Abstract The goal of this study is to show the role of time series models in predicting process and to demonstrate the suitable type of it according to the data under study. Autoregressive integrated moving averages (ARIMA) model is used as a common and a more applicable model. Univariate ARIMA model is used here to forecast egg production in some layers depending on daily data from the period of May to October 2018. Different criteria of the ARIMA model can be used to choose the suitable one such as the coefficient of determination (R2), mean absolute error (MAE), root mean square error (RMSE) and mean absolute relative percentage error (MARPE). Depending on these measures the autoregressive integrated moving average model with ordering (2,2,1) is considered the best model for forecasting process. The model fit statistics such as RMSE (331.520) which was low and the lowest BIC value (11.745) indicating that the model fit the data well. The high value of R2 (0.95) and MAPE (4.542) indicated a perfect forecasting model. Also, ARIMA model with ordering (1,2,2) is good in prediction process.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Evaluation of Immunostimulant Activity of Spirulina platensis (Arthrospira platensis) and Sage (Salvia officinalis) in Nile Tilapia (Oreochromis niloticus) Suhair A. Abdellatief1*, Afaf N. Abdel Rahman2 and Fatma D.M. Abdallah3 1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Sharkia, Egypt 2 Fish Diseases and Management Department, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Sharkia, Egypt 3Animal Wealth Development Department, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Sharkia, Egypt Article History: Received: 11/1/2018 Received in revised form: 5/2/2018 Accepted: 15/2/2018 Abstract Immunostimulants have been found to be attractive and promising agents for disease management in aquaculture. The current study aimed to assess the impacts of feeding with Spirulina platensis (SP) and Salvia officinalis (SO) for 28 days on the immune status of Nile tilapia (Oreochromis niloticus). A total of 180 Nile tilapia (30.6 ± 0.12 g) were divided into 3 groups (triplicates of 20 fish/group). Control group was fed on a basal diet only, while the other two groups were supplemented with SP (10 gm/kg diet) and SO (7.5 gm/kg diet) respectively. Both of SP and SO showed in vitro antimicrobial activity against Pseudomonas aeruginosa. The immune response of Nile tilapia supplemented with SP and SO revealed significant increases in lysozyme, nitric oxide activities and IgM titer with enhancement of IL-1β and TNF-α genes expression before and after infection with P. aeruginosa. Fish challenged with P. aeruginosa showed signs of infection with high mortality rate and low relative percentage survival which elevated to be 83% in SP group and 75% in SO group. It could be concluded that dietary supplementation with SP and SO improved immune response and protected Nile tilapia against infection. Moreover, SP showed better results than SO before and after infection.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Global Veterinaria 14 (5): 768-772, 2015 ISSN 1992-6197 © IDOSI Publications, 2015 DOI: 10.5829/idosi.gv.2015.14.05.94231 Corresponding Author: EL-Shimaa M. Roushdy, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt. E-mail: shimaa_production@yahoo.com. 768 Evaluation of Mortality in Selected Body Weight Lines of Japanese Quail Using Survival Analysis D.M. Fatma and M.R. EL-Shimaa Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt Abstract: Quail raising has become an important poultry business in the world. The objective of this study was to carry out survival analysis to evaluate and quantify risk factors involved in mortality of Japanese quail. Survival analysis and Cox proportional hazards model used to describe mortality in Japanese quail with hatch weight and post hatch body weight as a risk factors. Weight is a variable change with time, so it considered time dependent covariate. Survival function distribution and Kaplain Meier curve showed that mortality was higher in the line selected for high compared to low and control line. Log- rank test used for testing equality of survival distributions for the different levels of selected lines (Log-Rank value = 9.898) resulted P value = 0.007 which is a highly significant. Mortality declined when posthatch body weight increased. Body weight at hatch did not significantly affect mortality. However, posthatch body weight (BW) affects mortality significantly with P- value (0.011) and hazard ratio (1.009). Any factors affect growth after hatching may likely have a direct impact on mortality. Deficiency of water, feed, warmth and potential negative social interaction are factors that could affect mortality immediately after hatch. Through survival analysis, the present study has revealed that factors affecting post hatch Body weight negatively are likely risk factors for mortality in growing birds.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
International Journal of Statistics and Applications 2017, 7(3): 192-195 DOI: 10.5923/j.statistics.20170703.05 Statistical Assessment of Some Factors Affecting Calving Interval by Using Ordinal Logistic Regression in Holstein Cows Fatma D. M. Abdallah1, Eman A. Abo Elfadl2,* 1Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt 2Department of Animal Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Egypt Abstract Background & objectives: Calving interval considered an important trait throughout Holstein dairy cow's life. There are many risk factors which have a great impact on it. In the line with this consideration, the purpose of this study is to apply ordinal logistic regression model to estimate the effect of these risk factors on calving interval. Methods: Ordinal logistic regression analysis was used to estimate the odds ratio (OR) and probability of Holstein dairy cows conception for 3400 lactation records from Dina farms company, Egypt. The data was collected over a period extended from 1998 to 2010. The logit link function was used to predict the probability of occurrence of pregnancy using SPSS version 20.0, USA. Results: The odds ratio showed that the likelihood of pregnancy in cows with different parities was 0.931, 0.787, 0.634 and 1.000 for lactation order 2, 3, 4 and 5 respectively. Odds ratio of pregnancy of cows calving in winter were higher than those calving in summer, it was 1.234 and 1.000 respectively. Odds of different periods of days open were 0.586, 0.771, 0.638 and 1.000 respectively. Odds of different periods of dry period were 0.378, 0.525, 0.545 and 1.000 respectively. Conclusions: Findings showed fitting of this model to the data, it also showed the ability of ordinal logistic regression to provide measure which facilitates understanding of the important risk factors affecting calving interval.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
International Journal of Statistics and Applications 2018, 8(3): 129-132 DOI: 10.5923/j.statistics.20180803.03 Parametric Survival Models for Predicting of Pregnancy in Friesian Cattle Fatma D. M. Abdallah1, Eman A. Abo Elfadl2,* 1Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt 2Department of Animal Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Egypt Abstract Background & objectives: This work was performed to apply different parametric survival models instead of nonparametric ones for predicting pregnancy in Friesian dairy cattle by using days open as a time variable. The models used were exponential, normal, log-normal, Weibull, logistic, log logistic and smallest extreme value. Data for present study were obtained from animal records belongs to different Dakhalia farms (n = 1842) Covering the period between 2009 and 2011. Variables included in this study were days open as a dependent variable and the independent variables were: age at calving, dry period, calving interval, season, and lactation order. The survival time data were modeled by using life data regression procedure of Statgraphics statistical package program. Model parameters were estimated and comparisons among models were done based on Akaike Information Criterion (AIC). The Weibull model was the best option for evaluating time till occurrence of pregnancy where it had the smallest (AIC) value. It also showed a good fit with the studied data. This Weibull survival model can be used to predict the length of time from calving to conception in Friesian. But the Logistic was not appropriate to describe the dataset
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Statistical Modelling of Categorical Outcome with More than Two Nominal Categories Fatma D.M. Abdallah* Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt *Corresponding author: Nour_stat2013@yahoo.com Received August 13, 2018; Revised October 04, 2018; Accepted December 04, 2018 Abstract This paper aims to explain and apply an important statistical method used for modelling categorical outcome variable with at least two unordered categories. Logistic regression model especially multinomial logistic type (MNL) model is the best choice to model unordered qualitative data. A simulation study was done to examine the efficiency of the model in representing categorical response variable. Three explanatory variables (age, species, and sex) are used for discrimination. While the outcome variable was Rose Bengal Plate Test (RBPT) results which has four outcome categories (negative, positive, false positive, and false negative). Therefore, logit model will be utilized to model this data. MNL models were fitted using SPSS packages and parameters estimated depending on maximum likelihood (MLE) by the Newton-Raphson algorithm. This model depends mainly on two estimates to interpret the results, they are the regression coefficient and the exponentiated coefficients which known as the odds ratio. This model was a good fitted for description the data of 500 values of Rose Bengal Plate Test results of Brucella in sheep and goat species. The results showed fitting of the model to the data with highly significant likelihood ratio statistic for the overall model (P value = 0.000**). Wald test was significant for all variables in positive category and this indicated that age, species and sex are good predictors for test results. The odds ratio in case of positive category for age, species and sex was 1.589, 0.214 and 0.133 respectively. Keywords: multinomial logistic regression, odds ratio, Rose Bengal Plate Test (RBPT), maximum likelihood and pseudo R2 Cite This Article: Fatma D.M. Abdallah, “Statistical Modelling of Categorical Outcome with More than Two Nominal Categories.” American Journal of Applied Mathematics and Statistics, vol. 6, no. 6 (2018): 262-265. doi: 10.12691/ajams-6-6-7.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Using Discriminant Analysis and Artificial Neural Network Models for Classification and Prediction of Fertility Status of Friesian Cattle Eman A. Abo Elfadl1,*, Fatma D. M. Abdallah2 1Department of Animal Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Egypt 2Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt *Corresponding author: emmy_f1984@yahoo.com Abstract Background & objectives: This study was undertaken to compare the accuracies of Discriminant analysis model (DA) and Artificial neural networks model (ANN) for classification and prediction of Friesian cattle fertility status by using its reproductive traits. Methods: Data was collected through field survey of 2843 animal records of Friesian breed belongs to El Dakhalia province farms, Egypt. Data was covering the period extended from 2010 to 2013. The samples of dairy production sectors were selected randomly. Data was collected from valid farm records or the structured questionnaires established by the researcher. Results: The results of classification accuracy indicated that the artificial neural network (ANN) model is more efficient than the discriminant analysis (DA) model in expressing overall classification accuracy and accuracies of correctly classified cases of fertility status for Friesian cattle. The results showed that The ANN models had shown the highest classification accuracy (93.6%) for year (2010) while, it was (79.9%) for DA. The comparison of overall classification accuracies clearly favored the supremacy of ANN over DA. The results also were confirmed by the areas under Receiver Operating Characteristic Curves (ROC) captured by ANN and DA. ROC curves are used mainly for comparing different discriminating rates. Areas under ROC curves were higher in case of ANN models across the different years compared to DA models. The differences in accuracies were also significant at 5% level of significance with p-value 0.005 by using Paired Sample t-test. From all of the above we can conclude that artificial neural network model was more accurate in prediction and classification of fertility status than a traditional statistical model (Discriminant analysis). Keywords: artificial neural networks, discriminant analysis, prediction, classification, ROC curve and fertility status Cite This Article: Eman A. Abo Elfadl, and Fatma D. M. Abdallah, “Using Discriminant Analysis and Artificial Neural Network Models for Classification and Prediction of Fertility Status of Friesian Cattle.” American Journal of Applied Mathematics and Statistics, vol. 5, no. 3 (2017): 90-94. doi: 10.12691/ajams-5-3-1.
Fatma Desouky Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Zagazig Veterinary Journal, ©Faculty of Veterinay Medicine, Zagazig University, 44511, Egypt. Volume 47, Number 2, p. XXX, June 2019 DOI: 10.21608/zvjz.2019.11121.1034 RSEARCH ARTICLE Application of Different Biostatistical Methods in Biological Data Analysis Khairy M. El-Bayomi, Fatma D. Mohamed, Mahmoud S. El-Tarabany and Hagar F. Gouda* Animal Wealth Development Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt Abstract Logistic regression is one of the popular methods used in genetic data analysis. That is applied to predict a categorical binary dependent variable on basis of predictor variables, and to test the probability of getting a particular value of the dependent variable that is related to the explanatory variable. The objective of this study is to highlight the crucial role of biostatistical methods in increasing the accuracy of the results in veterinary and biological practices. Statistical analysis of previously published data in the National Research Center, Dokki, Giza, Cairo, Egypt was done using SPSS version, 24 to predict hepatocellular carcinoma metastasis by knowing the genotypes, age, and gender of the patients. The genotypes and gender displayed a significant effect on metastasis (P < 0.05) while age had no significant effect on metastasis (P > 0.05). There are other types of data (animal breeding and production) which were analyzed by repeated measures ANOVA and principal component analysis (PCA). The repeated measures ANOVA is equivalent to normalized ANOVA, but for related, not independent groups. Data of this test was obtained from a study aimed to measure body weight of three breeds of rabbits at 4 time points 4th, 6th, 8th and 10th weeks of the experiment. The main effect of breed types of rabbits was significant (P < 0.05), the time (weeks) was highly significant (P < 0.001) and their interaction was also highly significant (P < 0.001). Principal component analysis (PCA) is used to reduce a large set of variables to a small set that still contains most of the information in the large set. A reduced set is easier to analyze and interpret. Data with 6 variables reduced to only 2 variables where initial eigenvalues were > 1 for two variables and their values were (2.768 and 1.147).
Mohamed Elsayed Mohamed Hassan Badawy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Attia, G. A.; Hassanein, E. I.; El-Eraky, W.A.; El-Gamal M.F.; Abd El-Razik, W.M.; Badawi. M.E. (2014): Effect of Supplementation of the Broiler Diets by Different Sources of Zinc and/or Iron. The 1st International Conference On The Impact of Environmental Hazards on Food Safety, august 20th, 2014 at Faculty of Veterinary medicine, Zagazig University.
Mohammed Abdelaziz Elsayed Labda
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Veterinary medicine
Walid Rezk Alghareeb Elsaied
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
ANTIBIOTIC RESIDUE LEVELS IN CAMEL, CATTLE AND SHEEP TISSUES USING LC-MS/MS METHOD W. R. El-Ghareeb1,2, Z. Sh. Mulla1, A. M. A. Meligy3,4, W. S. Darwish2 and A. M. Edris1 1Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia 2 Food Control Department, Faculty of Veterinary Medicine, Zagazig University 44519, Egypt 3Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Saudi Arabia 4Physiology Department, Plant Protection Research Institute (PPRI), Agricultural Research Centre (ARC), Giza, Egypt Abstract Antimicrobials are very essential in prevention and control of infectious diseases for both humans and animals. However, the unregulated use of the antimicrobials may lead to several adverse health effects, such as development of multidrug resistant microbial strains, allergic and anaphylactic reactions. Saudi Arabia is one of the major countries in Middle East and Arabian Peninsula with a drastic increase in the livestock production. However, there is a clear lack of information about the current situation of antimicrobial residues in meat and edible offal intended for human consumption in Saudi Arabia. Therefore, this study screened the residue levels of nine antimicrobials with the most common use in Saudi Arabia veterinary medical field. These antimicrobials were enrofloxacin, ciprofloxacin, tylosin, erythromycin, tetracycline, oxytetracycline, chlortetracycline, sulfamethazine and sulfaquinoxaline. The tested samples included muscles, livers and kidneys of camel, cattle and sheep slaughtered at Al-Ahsa, Saudi Arabia. Antimicrobial residues in the tested samples was quantitatively estimated using liquid chromatography tandem mass spectrometry (LC–MS/MS). Sulfamethazine was detected at higher levels compared with the maximum residual limits (MPL) established by the regulatory authorities. Therefore, the effect of different cooking methods on sulfamethazine residues was investigated. The achieved results indicated occurrence of antimicrobial residues in the examined samples at levels below the recommended MPL, except for sulfamethazine that was detected at higher levels. Six antimicrobial residues were detected in samples collected from sheep; however, only three antimicrobials were detected in camel and cattle. Efficient heat treatment of the meat contaminated with sulfamethazine significantly reduced the residue load of sulfamethazine. In conclusion, efficient cooking of meat and observing the withdrawal periods of different antimicrobials are advisable to reduce human exposure to antimicrobial residues via meat consumption. مكان النشر: The Journal of Animal and Plant Sciences, August (2019).
Walid Rezk Alghareeb Elsaied
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
ASSESSMENT OF BIOGENIC AMINES CONTENT IN FRESH CATTLE LIVERS DURING CHILLING STORAGE AND PAN-ROASTING Elsaid A. Eldaly1, Mohamed A. Hussein1, and Waleed R. El-Ghareeb 1, 2 1 Food Control Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Egypt 2 Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia Abstract The levels of biogenic amines in addition to microbial and chemical parameters of fresh cattle livers were determined. The influence of chilling at 0 ± 1 °C, 4 ± 1 °C and pan-roasting on beef liver quality and safety was investigated. The obtained results revealed that the mean values of pH, Enterobacteriaceae count, total volatile nitrogen (TVN) and thiobarbituric acid (TBA) were 6.86 ± 0.03, 3.08 ± 0.8 log10 CFU /g, 16.09 ± 0.08 mg N/100 g and 0.18 ± 0.02 mg malonaldehyde /kg, respectively. Liver samples were contained high levels of spermidine (up to 5.1±0.99 mg/kg), and low levels of histamine and cadaverine. Therefore, beef liver constitutes one of the richest dietary sources of spermidine. During refrigerated storage, there were significant bacterial and chemical changes: the pH decreased, TVN increased, and the levels of most of the naturally occurring amines increased at rates which were faster at higher storage temperature. During the pan-roasting at 180°C for 5 min, the levels of the biogenic amines increased significantly. A shelf life of up to 6 and 4 days during storage at 0 ± 1 °C and 4± 1 °C, respectively, is recommended. مكان النشر: Japanese Journal of Veterinary Research 64 (Supplement 2): S217-223. (2016)
Walid Rezk Alghareeb Elsaied
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
METAL CONTENTS IN THE EDIBLE TISSUES OF CAMEL AND SHEEP: HUMAN DIETARY INTAKE AND RISK ASSESSMENT IN SAUDI ARABIA Waleed R. El-Ghareeb1, 2, Wageh S. Darwish1 and Ahmed M. A. Meligy3, 4 1 Food Control Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Egypt 2 Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia 3 Department of Central Lab of Chemical Analysis, College of Veterinary Medicine, King Faisal University, Saudi Arabia 4 Physiology Department, Plant Protection Research Institute, Agricultural Research Centre, Giza, Egypt Abstract Camel and sheep meats are considered major sources of animal-derived protein, vitamins and minerals in certain parts of the world such as Arabian Peninsula, India and Middle East countries. Despite these health benefits, the safety of sheep and camel meat may be compromised by the presence of heavy metals. The monitoring of metal concentrations is therefore important to ensure compliance with food safety regulations and consequent consumer protection. This study was undertaken to estimate the toxic metals (lead, cadmium and arsenic) and the essential trace elements (copper, zinc and iron) contents in the edible tissues (muscle, livers and kidneys) of both camel and sheep slaughtered at Al-Ahsa, Saudi Arabia. The dietary intake and human health risk assessment of the examined metals due to consumption of these tissues by Saudi population were estimated. The results indicate that the tested metals were detected in all the tissue samples with variable concentrations. Residual concentrations of all examined metals were within the maximum permissible limits set by European Union, Food and Agricultural Organization except for the arsenic. Human health risk assessment revealed that the detected concentrations of cadmium and lead might not possess health hazards. Nevertheless, care is imperative regarding As especially in Saudi Arabia because of the excessive meat consumption. مكان النشر: Japanese Journal of Veterinary Research 67(1). (2019)
Walid Rezk Alghareeb Elsaied
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN CAMEL MEAT: PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY Waleed R. El-Ghareeb, Faisal S. Almathen1, Mahmoud M. Fayez and Raed A. Alsultan 1 Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine and Animal Resources, King Faisal University 2 Food Control Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Egypt. 3 Veterinary Serum and Vaccine Research Institute, Cairo, Egypt. 4 Ministry of Environment, Water and Agriculture, Saudi Arabia. Abstract This study is an initiative study intended to investigate the prevalence and antibiotic susceptibility of Staphylococcus aureus and MRSA obtained from fresh camel meat retailed in Al-Hasa, Saudi Arabia. The survey has been conducted for five months where fresh camel meat were microbiologically analyzed to isolate S. aureus using culture media and VITEK2 technique. The Identification of S. aureus was done by DNA expression of gene specific 16S rRNA, while mecA gene expression was recognized in the identified MRSA isolates using PCR. The recorded prevalence of S. aureus was 10.7 % (20/187) from raw camel meat. Three isolates out of twenty S. aureus isolates were confirmed to be MRSA. Susceptibility to 10 antimicrobials was estimated using the disc diffusion method. These results suggested that MRSA is found in camel meat retailed at Al-Hasa, Saudi Arabia. We recommend that, surveillance protocol should be embraced in meat safety and public health programs. مكان النشر: Slovenian Veterinary Research Journal. (2019).
Walid Rezk Alghareeb Elsaied
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
PREVALENCE AND ANTIBIOTIC RESISTANCE PATTERN OF E. COLI AND SALMONELLA ISOLATES FROM ZAGAZIG ABATTOIR Ehab Nabawy, Ahmed E. Tharwat and Waleed Rizk EL-Ghareeb 1 Department of Veterinary public health, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt 2 Department of Food control, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt 3Department of Veterinary Public Health and Animal Husbandry, Collegeof Veterinary Medicine,King Faisal University, Saudi Arabia Abstract The effect of abattoir environment on the level of carcasses contamination was studied; this task was achieved after collection of 130 samples from Zagazig abattoir represented by hundred swabs of abattoir walls, abattoir floors, knives, worker’s hand, cattle and camel carcass surfaces. In addition to thirty water samples collected from the input water, carcass washing water, wastewater (10 of each). The prevalence of Escherichia coli (E.coli) was 60, 100, 30, 30, 00, 60, 100, 30, 70, 40, 60, 20, and 30%. Meanwhile the prevalence of Salmonella was 40, 70, 10, 00,00, 30, 80, 10, 40, 00, 20, 00, 10% in examined walls, floors, knives, worker’s hand, input water, washing water, waste water, cattle thigh, cattle shoulder, buffalo thigh, buffalo shoulder, camel thigh and camel shoulder, respectively. Enterohemorrhagic E.coli O26:H11 15/130 (11.53%) and Salmonella typhimurium 9/130 (6.92%) were predominant species among examined samples. Hundred percentage of isolated E.coli was resistant to penicillin and sensitivity was (77.8%) and (92%) for ciprofloxacin and gentamicin. Salmonella species showed 100% resistance to streptomycin and sensitivity was (77.4%) and (93.5%) for ciprofloxacin and gentamicin. Both of E.coli and Salmonella isolates showed multi antibiotic resistant (MAR). The public health importance of isolates was discussed. مكان النشر: 5th International Food Safety Conference Damanhur University October 2018
Walid Rezk Alghareeb Elsaied
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- Faculty Research Area On Staff Site
PREVALENCE OF MULTIDRUG RESISTANT SHIGA TOXIN-PRODUCING ESCHERICHIA COLI IN CATTLE MEAT AND ITS CONTACT SURFACES W.S. Darwish 1, A.S. Atia 2, W.R. El-Ghareeb 1,3 , A.E. Elhelaly 4,5 1. Food Control Department, Faculty of Veterinary Medicine, Zagazig University 44519, Egypt 2. Department of Veterinary Hygiene, Faculty of Veterinary Medicine, Zagazig University 44519, Egypt 3. Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia 4. Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt 5. Center for Emerging Infectious Diseases, School of Medicine, Gifu University, Gifu, Japan Abstract Shiga toxin-producing Escherichia coli (STEC) are group of E. coli causing bloody diarrhea. The goal of this survey was to determine the prevalence of multidrug resistant shiga toxin-producing E. coli in cattle meat and its contact surfaces. Swab samples (n=120) were randomly collected from meat and contact surface of butchery shops in Sharkia province, Egypt. Prevalence of E. coli was examined using culture, biochemical, and serological methods. Identification of shiga toxin-encoding genes (stx1 and stx2) in the E. coli serotypes was done using multiplex polymerase chain reaction. Screening of multidrug resistance profile was done using the disk-diffusion method. Data were analyzed using JMP statistical package, SAS Institute Inc., Cary, NC. The prevalence rates of E. coli in the chuck, round, masseter muscles, cutting boards, walls, and floors were 20, 10, 30, 50, 40, and 60%, respectively. Among the isolates, E. coli O111:H4 and E. coli O26:H11 harbored the two mentioned genes. E. coli O86 and E. coli O114:H21 harbored only stx1; while E. coli O55:H7 encoded only stx2. Just E. coli O124 had no express of stx1 and stx2. The isolated E. coli serovars showed a multidrug resistance profile. Considering the results of this study, strict hygienic procedures should be followed to avoid or reduce carcass cross contamination. In addition, proper handling and efficient cooking of meat are highly recommended by consumers to reduce the risk of human exposure to STEC. مكان النشر: Journal of Food Quality and Hazards Control 5 (2018) 146-153
Walid Rezk Alghareeb Elsaied
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SOME CHEMICAL RESIDUES IN SMOKED HERRING Waleed Rizk El-Ghareeb - Food Control Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Egypt. - Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia. Abstract Levels of twenty-two organochlorine pesticides (OCPs) and five heavy metals (As, Cd, Pb, Hg & Al) were assessed in forty smoked herring (Clupea harengus) fish samples collected weekly between October 2015 and May 2016 from Zagazig city markets. Samples were examined for their chemical residual levels of DDT compounds (DDTs), hexachlorocyclohexane isomers (HCHs), lindane (c-HCH), Aldrin, dieldrin, endrin, hexachlorobenzene (HCB), toxaphene, and chlordane compounds. Endrine, OP-DDE and PP-DDT were not existed in any fish samples. The average range of OCP levels between the herring samples was 2.48–264.00 ng g−1 (lipid weight), 0.34–35.64 (wet weight). Total-Ƴ-HCH and total-HCB, were the most predominant contaminants in the fish samples (100%) while, Aldrin, trans-chlordane, OP-DDD & PP-DDD were the lowest (10%). As general, the order of contamination pattern of OCPs was HCHs, HCB > Heptachlor > DDTs. There was no relation between content of lipid in herring fish samples and the contaminant levels. The contents of the organochlorine residues and heavy metals observed in all of the analyzed contaminated samples were less than the maximal permissible limits fixed by different local and international organizations for fish set by FDA. EDIs (Estimated daily intakes) through dietary consumption of smoked herring which were less than the recommended acceptable daily intakes (ADIs) set by FAO/WHO. مكان النشر: 4th International Food Safety Conference, University of Sadat City, 4/11/2017
Walid Rezk Alghareeb Elsaied
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THE EFFECT OF ROSEMARY EXTRACT AND LACTIC ACID ON THE QUALITY OF REFRIGERATED BROILER FILLETS Mohamed A. Hussein1, Waleed R. El-Ghareeb1,2 and Mohammed A. F. Nasr3 1 Department of Food Control, Faculty of Veterinary Medicine, Zagazig University, Egypt. 2 Department of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Saudi Arabia. 3 Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt. Abstract The current study investigated the effect of rosemary extract (0.2% RE) and lactic acid (1% LA) on some freshness, bacterial parameters and formation of biogenic amines during refrigeration of broiler fillets. Ninety broiler fillet samples were divided into three groups (each 30). The control group was dipped in sterile distilled water, while the RE and LA groups were dipped in rosemary extract 0.2% (w/v) and lactic acid 1% (w/v), respectively. Sensory evaluation, pH, total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), total psychrotrophic and Enterobacteriaceae counts were performed at zero time and at 3 days interval until the group were rejected from sensory analysis. Organoleptic scores were unacceptable after the 9th, 12th and 15th day of refrigeration in control, RE and LA groups, respectively. TVB-N was the lowest in LA group (3rd day; 4.36 ± 0.12, 6th day; 5.62 ± 0.7 and 9th day; 10.13 ± 0.98) when compared with the RE and control groups. Moreover, TBARS was the highest in the control group (3rd day; 0.22 ± 0.06, 6th day; 0.39 ± 0.07 and 9th day; 0.78 ± 0.09) when compared with the RE and LA groups. LA group showed the lowest number of psychrotrophic bacteria during refrigeration period when compared with the other groups. Enterbacteriaceae was detected at zero, 3rd and 6th day in control, RE and LA groups, respectively. This study concluded that dipping in LA 1% or RE 0.2% reduce the psychrotrophic and Enterobacteriaceae bacteria of broiler fillet and increased the acceptability of refrigerated fillet, decreased the biogenic amines formation and rancidity. Therefore, broiler fillets dipped in RE 0.2% or LA 1% can be used up to 12 or 15 days when refrigerated at 4°c C. مكان النشر: Journal of Food Science and Technology; 55 (12): 5025–5034 (2018).
Shereen Ahmed Taaha
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The Effect of Exercise Program on The Rate of Emotional Intelligence and The Level of Some of The Components of Fitness For The Students of The Faculty of Veterinary Medicine / University of Zagazig
Khaled Mohammed Ali AlMarakby
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Characterization of progesterone profile, physiological responses, milk composition and blood biochemical and hematological indices at the early stage of lactation in goats. Mahmoud S. El-Tarabanya, Tamer M. Abdel-Hamida, Omar A. Ahmed-Faridb, and Khaled M. Al-Marakbyc a Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. b Physiology department, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt. c Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia, Egypt. Abstract The aim of this research was to describe the progesterone profile, physiological response, milk composition, and blood chemistry at the early stage (DIM 30-90 days) of lactation (E1:30-50; E2:50-70; E3:70-90 days) in Baladi goats under Egyptian conditions. The serum progesterone level was significantly reduced with the progress of the early lactation period to reach the least concentration (0.24 ng/ml) at the E3 stage of lactation (P=0.001). The daily milk yield was significantly increased with the progress of the lactation to reach the peak at the E2 stage of lactation (P=0.015). The percentage of milk fat was significantly decreased with the progress of the early lactation period (P=0.032). However, the percentages of total solids and SNF were significantly increased in E2 and E3 stages when compared with the E1 stage (P=0.001 and 0.018, respectively). The serum glucose and total antioxidant capacity were considerably reduced with the progress of the lactation period (P=0.047 and 0.039, respectively). In conclusion, Baladi goats showed a decreased serum progesterone level with the progress of the early lactation period and produce milk with a relatively stable protein and lactose contents. Furthermore, Baladi does able to maintain the stability of most blood biochemical parameters during such period.
Khaled Mohammed Ali AlMarakby
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Effect of exogenous hormone treatments on spermatogenesis in male grey mullet out of the spawning season. Abdel-Halim A. El-Darawany a , Amira Moustafa b, Khaled M. Al-Marakby a, Abdel-Mageed E. Nasr a, Mohamed A. Naiel a, and Yaser H. Elewa c. a Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia,Egypt. b Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. c Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. Abstract The aim of the present study is to investigate the effects of human chorionic gonadotropin (hCG), carp pituitary extract (CPE), melatonin, and adrenal gland extract (AE) administered either separately or in combination on the induction of testicular maturation and spermatogenesis in the thin-lipped grey mullet, Liza ramada, out of its spawning season. The results revealed that testes obtained from fish out of their reproductive season have empty seminiferous tubules with germ cells or Sertoli cells markers barely expressed and a low gonadsomatic index (GSI). A significant increase in GSI levels was observed by different hormone treatments. As predicted, hormone treatments showed an obvious stimulation of germ cells proliferation and testicular maturation as indicated by the immunohistochemical expression of germ cells and Sertoli cells markers with the highest values achieved by hCG/AE treatment. We conclude that hormone treatments may be a potential strategy for the induction of spermatogenesis and testes maturation.
Khaled Mohammed Ali AlMarakby
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Effect of lunar cycle on some reproductive aspects of female goats. Abdel-Halim A. El-Darawanya, Mahmoud S.El-Tarabanyb,Khaled M. Al-Marakbya, and Mostafa A. Attac a Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia,Egypt. b Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. c Biological Applications Department, Radioisotopes Applications Division, NRC, Atomic Energy Authority, Inshas, Sharkia, Egypt. Abstract The aim was to evaluate the possible effects of different lunar phases at birth on the pre-pubertal changes in the body measurements, blood parameters and hormonal profile of female goats. Based on the birth date, 36 female Nubian kids (3 months of age) were selected to equally represent the new (NL), full (FL) and old (OL) phases of the lunar cycle. Female goats in the FL group showed significantly higher body weights at weeks 20, 24 and 28 of age compared to the OL group (P = 0.050, 0.033 and 0.046,respectively). Female goats in the FL group exhibited estrus signs earlier than those in the OL group (P = 0.013). At the age of puberty, the values of Spinnbarkeit and ferning arborization of cervical mucus in the FL group were significantly greater than the NL and OL groups (P = 0.001 and 0.040, respectively). At weeks 26 and 27 of age, female goats in the FL group had significantly greater serum progesterone (P = 0.006 and 0.001, respectively) than did the NL and OL groups. In conclusion, the FL group reached the puberty at an early age and exhibited higher cyclic progesterone levels than did the NL and OL groups.
Khaled Mohammed Ali AlMarakby
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- Faculty Research Area On Staff Site
Effect of synchronization protocols on reproductive indices, progesterone profile and fertility under subtropical environmental conditions in repeat breeder Holstein cows. Mahmoud S. El-Tarabany a and Khaled M. Al-Marakby b a Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. b Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia,Egypt. Abstract The objectives were to evaluate the reproductive indices and survival analysis of pregnancy outcomes in multiparous repeat breeder Holstein cows (n = 557). The cows were synchronized to ovulate by Ovsynch, new controlled internal drug release device (N-CIDRsynch), and once-used CIDR device (U-CIDRsynch). The pregnancy per AI at 28 days post-insemination (P/AI 28) in the N-CIDRsynch group (28.75%) was significantly (COR = 1.49; p = 0.011) greater than that reported in the Ovsynch (23.46%) and U-CIDRsynch (21.73%) groups. Furthermore, the pregnancy per AI at day 75 post-insemination (P/AI 75) in the N-CIDRsynch group was significantly greater than the Ovysync group (COR = 1.35; p = 0.050). The repeat breeder cows received a N-CIDR device had a significantly higher progesterone level on day 2 and day 4 of CIDR insertion (1.38 and 1.67 ng/ml, respectively) than those received a U-CIDR device or the control group (p = 0.012 and 0.001, respectively). The Cox regression model recorded significant associations for synchronization protocols, THI at the TAI and season of calving with the hazard of P/AI 28 and P/AI 75 (p = 0.044 and 0.046; 0.001 and 0.005; 0.003 and 0.001, respectively). Multiparous repeat breeder cows (>3) had a lower hazard ratio (HR) of P/AI 28 than that reported in the reference (2nd parity) group (HR = 0.74, p = 0.050). The repeat breeder cows inseminated at 76–80 and >80 temperature-humidity index (THI) had significantly lower HR of P/AI 28 than those inseminated at the baseline (<70) THI value (HR = 0.73 and 0.30, p = 0.036 and 0.001, respectively). The current results indicate that the use of N-CIDR synch protocol may achieve satisfactory pregnancy outcomes in repeat breeder cows.
Khaled Mohammed Ali AlMarakby
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- Faculty Research Area On Staff Site
Impact of lunar phase at birth on testicular morphology, semen characteristics and blood chemistry of male goats. Mahmoud S. El-Tarabany a, Abdel-Halim A. El-Darawany b, Akram A. El-Tarabany c and Khaled M. Al-Marakby b a Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. b Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia,Egypt. c Biological Applications Department, Radioisotopes Applications Division, NRC, Atomic Energy Authority, Inshas, Sharkia, Egypt. Abstract The aim was to investigate the possible effects of different lunar phases at birth on the pre-pubertal changes in the body weights, blood parameters and hormonal profile of male goats. Based on the birth date, 33 male Nubian kids (3 months of age) were selected to represent the new (NL), full (FL) and old (OL) phases of the lunar cycle. The FL group exhibited the signs of puberty earlier than the NL and OL groups (P=0.011). At the age of puberty, bucks in the FL group had significantly higher ejaculate volume (P=0.010), sperm cell concentration (P=0.004), mass motility (P=0.016) and the percentage of live spermatozoa (P=0.008) as compared to the NL and OL groups. Additionally, male goats in the FL group showed significantly higher serum testosterone levels at week 25, 26, 27 and 28 of age compared with the NL and OL groups (P=0.002, 0.013, 0.038 and 0.004, respectively). In conclusion, the growing males in the FL group reached the puberty earlier than the NL and OL groups. Moreover, this study may help to maximize the semen quality and develop more effective AI strategies in the modern goat production systems.
Nadya ebasiry Elsayed
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BACKGROUND: Gentamicin is widely used broad spectrum aminoglycoside antibiotic. Despite its beneficial effects, gentamicin has considerable nephrotoxic effects. Salicylic acid is a phenolic compound that has anti-inflammatory, analgesic and antipyretic effect. It has also antioxidant activity that can counteract oxidative damages induced by adverse conditions in animals. OBJECTIVES: The work aims to detect the harmful changes in the rat kidney that occur after administration of gentamicin and to determine whether salicylic acid treatment attenuates gentamicin - induced nephrotoxicity. MATERIAL AND METHODS: Fifty healthy adult male Wister albino rats were obtained from the breading animal house, Faculty of Veterinary Medicine, Zagazig University. These animals were divided randomly and equally in to five groups. Each group contains ten rats. Group 1: Included control animals. Group 2: Included salicylic acid-treated animals. Group 3: Included gentamicin-treated animals. Group 4: Included animals treated with salicylic and gentamicin at the same time. Group 5: Included animals treated with gentamicin and remain for recovery. The rats were anesthetized with ether inhalation and sacrificed. The kidneys were removed and processed for light and electron microscopic examination. RESULTS: The histological study revealed that gentamicin causes severe nephrotoxicity. Exposure to gentamicin caused necrosis of tubular epithelial cells. The glomeruli were also affected. On the other hand, salicylic acid administration protected kidney tissue against the nephrotoxic effect caused by gentamicin treatment. Recovery from gentamicin treatment could occur spontaneously but it was slow and incomplete. CONCLUSION: Gentamicin administration leads to harmful changes in the structure of the rat kidney. Spontaneous recovery could occur but it is slow and incomplete. These nephrotoxic changes can be protected by co-therapy with salicylic acid